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GHK-Cu

GHK-Cu stands for glycyl-L-histidyl-L-lysine bound to copper (II) — a naturally occurring tripeptide complex first identified in human plasma in the 1970s. It is found throughout the body in blood, saliva, and urine, but its levels decline significantly with age. At age 20, concentrations are much higher than they are by age 60, which correlates with slower healing, reduced skin quality, and diminished hair health. Unlike drugs that target a single pathway, GHK-Cu acts as a bioregulatory molecule, supporting a wide range of cellular processes. Its main functions include: → Wound healing and tissue repair – accelerates skin recovery and reduces scarring. → Collagen and elastin synthesis – strengthens the extracellular matrix that supports both skin and hair follicles. → Anti-inflammatory signaling – lowers damaging cytokines that contribute to follicle miniaturization and scalp irritation. → Antioxidant defense – enhances natural protection against oxidative stress, a major factor in aging and hair loss. → Gene expression modulation – influences thousands of genes related to growth, repair, and metabolic regulation. Because of these properties, GHK-Cu has been widely studied in dermatology and regenerative medicine. More recently, its ability to stimulate hair follicles, improve scalp circulation, and create a healthier growth environment has made it a promising candidate for hair restoration.